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In the manga’s story, cells work in a “black“ environment in the body of a human in poor health. The person drinks and eats too much, has insufficient physical activity, and has high stress.
Yuri is frustrated that her childhood friend, Taku, is not very masculine. She wants to level-up their relationship but Taku just can't make any bold or sexual advances. Then one day an evil spirit (youma) pops in on Taku and tells him about a prophecy foretelling of a time when Taku's offspring will save the world. After finishing the tale, the youma immediately puts a curse on Taku's balls in order to stop the prophecy from coming true. But that curse has made Taku more feminine than ever. Is Yuri's dreams of a love-love relationship with Taku over, or can she help Taku find his masculinity?